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KMID : 0363219960340010093
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Korean Journal of Dermatology
1996 Volume.34 No. 1 p.93 ~ p.101
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A Clinical Study of Chronic Cutaneous GVHD
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신현민
이동원/이종육/한치화/김춘추/조백기
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Abstract
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Background :
@EN With progressive improvement in the fraction of long-term surviviors, chronic GVHD has emerged as a increasingly frequent complication of allogenic bone marrow transplantation. Except for a few case reports, there has been no clinical study
of
of
chronic cutaneous GVHD in Korea so far.
@ES Objective :
@EN In the present study we palnned to investigate the clinical characteristics of chronic cutaneous GHD and to compare the clinical manifestation and incidence of chronic cutaneous GVHD in Korea with previous reports in U.S.A. and Europe.
@ES Methods :
@EN On the basis of the patients' charts and the records of bone marrow transplantation, we investigated the incidence of chronic cutaneous GVHD in Korean leukemia patients and studied the clinical manifestations of chronic cutaneous GVHD
ocurring
in 16
patients whose diagnosis was confirmed by histopathologic findings of skin biopsy.
We also analysed whether total body irrdiation before bone marrow transplantation, GVHD prophylaxis and presence of preceding acute GVHD affected chronic cutaneous GVHD.
@ES Results :
@EN 1. The incidence in chronic cutaneous GVHD in Korea was lower than that in Caucasian countries.
2. The onset was milder than that in Caucasias.
3. The clinical manifestation was earlier than that in Caucasians.
4. The relationship between the GVHD prophylaxis and incidence chronic cutaneous GVHD was not significant.
5. The incidence of chronic cutaneous GVHD in the presence of preceding acute GVHD was higher than in cases with no preceding acute GVHD.
@ES Conclusion :
@EN We speculate that the low incidence of chronic cutaneous GVHD and clinical characteristies differing from the reports in the U.S.A. and Europe might be unassociated with irradiation, GVHD prophylaxis or the presence of preceding acute GVHD
but
maybe
related to differences in genetic background. (Kor J Dermatol 1996;34(1) : 93~101)
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KEYWORD
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